Georg Jaeschke : rechercher sur Z-Library

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1

Guided Imagery for Arthritis and Other Rheumatic Diseases: A Systematic Review of Randomized Controlled Trials

Giacobbi, Peter R., Stabler, Meagan E., Stewart, Jonathan, Jaeschke, Anna-Marie, Siebert, Jean L., Kelley, George A.

Journal:

Pain Management Nursing

Année:

2015

Langue:

english

Fichier:

PDF, 539 KB

english, 2015

2

Highly Enantioselective Opening of Cyclic meso-Anhydrides to Isopropyl Hemiesters with Diisopropoxytitanium TADDOLates

Prof. Dr. Dieter Seebach, Dipl.-Chem. Georg Jaeschke, Dr. Yan Ming Wang

Journal:

Angewandte Chemie International Edition

Année:

1995

Langue:

english

Fichier:

PDF, 239 KB

english, 1995

3

Short Enzymatic Synthesis of L-Fucose Analogs

Wolf-Dieter Fessner, Claudius Goße, Georg Jaeschke, Oliver Eyrisch

Journal:

European Journal of Organic Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 326 KB

english, 2000

4

Hoch enantioselektive Öffnung cyclischer meso-Anhydride zu Isopropylhalbestern mit Diisopropoxytitan-TADDOLaten

Prof. Dr. Dieter Seebach, Dipl.-Chem. Georg Jaeschke, Dr. Yan Ming Wang

Journal:

Angewandte Chemie

Année:

1995

Fichier:

PDF, 248 KB

1995

5

ChemInform Abstract: Enzymes in Organic Synthesis. Part 15. Short Enzymatic Synthesis of L-Fucose Analogues.

Wolf-Dieter Fessner, Claudius Gosse, Georg Jaeschke, Oliver Eyrisch

Journal:

Année:

2000

Fichier:

PDF, 35 KB

2000

6

ChemInform Abstract: Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl] -4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist.

Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Buettelmann, Ramanjit Gill, Marie-Paule Heitz, Georg Jaeschke, Vincent Mutel, Gerhard Trube, Rene Wyler

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 38 KB

english, 2001

7

Enantioselective Total Synthesis of Callipeltoside A.

David A. Evans, Essa Hu, Jason D. Burch, Georg Jaeschke

Journal:

Année:

2002

Fichier:

PDF, 24 KB

2002

8

Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

Martin Morgenthaler, Eliane Schweizer, Anja Hoffmann-Röder, Fausta Benini, Rainer E. Martin, Georg Jaeschke, Björn Wagner, Holger Fischer, Stefanie Bendels, Daniel Zimmerli, Josef Schneider, François

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 529 KB

english, 2007

9

Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series

Simona M. Ceccarelli, Götz Schlotterbeck, Patrick Boissin, Martin Binder, Bernd Buettelmann, Steven Hanlon, Georg Jaeschke, Sabine Kolczewski, Ernst Kupfer, Jens-Uwe Peters, Richard H. P. Porter, Eric

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 448 KB

english, 2008

10

Enantioselective 1,4-Addition of Aliphatic Grignard Reagents to Enones Catalyzed by Readily Available Copper(I) thiolates derived from TADDOL. Preliminary communication

Dieter Seebach, Georg Jaeschke, Arkadius Pichota, Laurent Audergon

Journal:

Helvetica Chimica Acta

Année:

1997

Langue:

english

Fichier:

PDF, 268 KB

english, 1997

11

Synthesis of [3H]fenobam, a radioligand for the mGlu5 receptor

Thomas Hartung, Jens-Uwe Peters, Jürgen Wichmann, Christian Hubschwerlen, Georg Jaeschke

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2008

Langue:

english

Fichier:

PDF, 102 KB

english, 2008

12

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Bernd Büttelmann, Jens-Uwe Peters, Simona Ceccarelli, Sabine Kolczewski, Eric Vieira, Eric P. Prinssen, Will Spooren, Franz Schuler, Jörg Huwyler, Richard H.P. Porter, Georg Jaeschke

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 170 KB

english, 2006

13

Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure

Simona M. Ceccarelli, Georg Jaeschke, Bernd Buettelmann, Jörg Huwyler, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Richard Porter, Will Spooren, Eric Vieira

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 172 KB

english, 2007

14

Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment

David A. Evans, Jason D. Burch, Essa Hu, Georg Jaeschke

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2008

15

Resolution of racemic carboxylic acid derivatives by Ti-TADDOLate mediated esterification reactions—A general method for the preparation of enantiopure compounds

Dieter Seebach, Georg Jaeschke, Konstanze Gottwald, Keiji Matsuda, Roberto Formisano, David A Chaplin, Matthias Breuning, Gerhard Bringmann

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 909 KB

english, 1997

16

Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Büttelmann, Ramanjit Gill, Marie-Paule Heitz, Georg Jaeschke, Vincent Mutel, Gerhard Trube, René Wyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 158 KB

english, 2001

17

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

Georg Jaeschke, Richard Porter, Bernd Büttelmann, Simona M. Ceccarelli, Wolfgang Guba, Bernd Kuhn, Sabine Kolczewski, Jörg Huwyler, Vincent Mutel, Jens-Uwe Peters, Theresa Ballard, Eric Prinssen, Eric

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 206 KB

english, 2007

18

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP

Pari Malherbe, Nicole Kratochwil, Andreas Mühlemann, Marie-Thérèse Zenner, Christophe Fischer, Martin Stahl, Paul R. Gerber, Georg Jaeschke, Richard H. P. Porter

Journal:

Journal of Neurochemistry

Année:

2006

Langue:

english

Fichier:

PDF, 561 KB

english, 2006

19

Kurze Mitteilungen

M. Blösch, K. Flügel, M. Dornbusch, Paul Isenmann, H. Kumerloeve, G. Jaeschke, U. Schulz, J. Gaisler, D. Povolný, Z. Šebek, F. Tenora, J. Nicolai, Peter Kunkel, Dietrich Heidecke, George E. Watson

Journal:

Journal of Ornithology

Année:

1968

Langue:

german

Fichier:

PDF, 1.01 MB

german, 1968

20

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors

Andreas Mühlemann, Natalie A. Ward, Nicole Kratochwil, Catherine Diener, Christophe Fischer, Andy Stucki, Georg Jaeschke, Pari Malherbe, Richard H.P. Porter

Journal:

European Journal of Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 347 KB

english, 2006

21

Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP

Rebecca E. Nordquist, Sean Durkin, Georg Jaeschke, Will Spooren

Journal:

European Journal of Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 142 KB

english, 2007

22

Enantioselective Total Synthesis of Callipeltoside A

Jaeschke, Georg, Evans, David A., Hu, Essa, Burch, Jason D.

Journal:

Journal of the American Chemical Society

Année:

2002

Langue:

english

Fichier:

PDF, 53 KB

english, 2002

23

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

Aubin Michalon, Michael Sidorov, Theresa M. Ballard, Laurence Ozmen, Will Spooren, Joseph G. Wettstein, Georg Jaeschke, Mark F. Bear, Lothar Lindemann

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 905 KB

english, 2012

24

Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice

Amber R Salomons, Nathaly Espitia Pinzon, Hetty Boleij, Susanne Kirchhoff, Saskia S Arndt, Rebecca E Nordquist, Lothar Lindemann, Georg Jaeschke, Will Spooren, Frauke Ohl

Journal:

Behavioral and Brain Functions

Année:

2012

Langue:

english

Fichier:

PDF, 449 KB

english, 2012

25

Highly Enantioselective Ring Opening of Cyclic Meso -Anhydrides to Isopropyl Hemiesters with Ti−TADDOLates: An Alternative to Hydrolytic Enzymes?

Jaeschke, Georg, Seebach, Dieter

Journal:

Journal of Organic Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 115 KB

english, 1998

26

Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice

Michalon, Aubin, Bruns, Andreas, Risterucci, Céline, Honer, Michael, Ballard, Theresa M., Ozmen, Laurence, Jaeschke, Georg, Wettstein, Joseph G., von Kienlin, Markus, Künnecke, Basil, Lindemann, Lotha

Journal:

Biological Psychiatry

Année:

2014

Langue:

english

Fichier:

PDF, 986 KB

english, 2014

27

Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery

Klein, Jens, Heal, Jonathan R., Hamilton, William D. O., Boussemghoune, Thiamo, Tange, Thomas Østergaard, Delegrange, Fanny, Jaeschke, Georg, Hatsch, Anaëlle, Heim, Jutta

Journal:

ACS Synthetic Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.20 MB

english, 2014

28

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1 H -imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk,

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2015

29

mGlu5 receptor antagonists and their therapeutic potential

Jaeschke, Georg, Wettstein, Joseph G, Nordquist, Rebecca E, Spooren, Will

Journal:

Expert Opinion on Therapeutic Patents

Année:

2008

Langue:

english

Fichier:

PDF, 581 KB

english, 2008

30

Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Tian, Di, Stoppel, Laura J, Heynen, Arnold J, Lindemann, Lothar, Jaeschke, Georg, Mills, Alea A, Bear, Mark F

Journal:

Nature Neuroscience

Année:

2015

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2015

31

Tuberous Sclerosis Complex Tumor Suppressor-Mediated S6 Kinase Inhibition by Phosphatidylinositide-3-OH Kinase Is mTOR Independent

Anja Jaeschke, Joerg Hartkamp, Masao Saitoh, Wendy Roworth, Takahiro Nobukuni, Angela Hodges, Julian Sampson, George Thomas and Richard Lamb

Journal:

The Journal of Cell Biology

Année:

2002

Langue:

english

Fichier:

PDF, 2.69 MB

english, 2002

32

Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences

Peterlik, Daniel, Stangl, Christina, Bauer, Amelie, Bludau, Anna, Keller, Jana, Grabski, Dominik, Killian, Tobias, Schmidt, Dominic, Zajicek, Franziska, Jaeschke, Georg, Lindemann, Lothar, Reber, Stef

Journal:

Brain, Behavior, and Immunity

Année:

2016

Langue:

english

Fichier:

PDF, 1.84 MB

english, 2016

33

Results and evaluation of a first-in-human study of RG7342, a mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods

Sturm, Stefan, Delporte, Marie-Laure, Hadi, Salah, Schobel, Scott, Lindemann, Lothar, Weikert, Robert, Jaeschke, Georg, Derks, Michael, Palermo, Giuseppe

Journal:

British Journal of Clinical Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2017

34

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration

Lutkewitte, Andrew J., Schweitzer, George G., Kennon-McGill, Stefanie, Clemens, Melissa M., James, Laura P., Jaeschke, Hartmut, Finck, Brian N., McGill, Mitchell R.

Journal:

Food and Chemical Toxicology

Année:

2018

Langue:

english

Fichier:

PDF, 3.94 MB

english, 2018

35

Extraction of valuable compounds from Arthrospira platensis using pulsed electric field treatment

Jaeschke, Débora Pez, Mercali, Giovana Domeneghini, Marczak, Ligia Damasceno Ferreira, Müller, Georg, Frey, Wolfgang, Gusbeth, Christian

Journal:

Bioresource Technology

Année:

2019

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2019